Speaking Against (Blaspheme) the Holy Spirit: What is your take on "speaking against" or "blaspheming" the Holy Spirit? Unpardonable Sin (Blasphemy) & "Sin that Leads to Death": Do you think that the unpardonable sin is actually refusing God until the very end, and relates to the sin that leads to death in I John? [Matthew 12:32, Matthew 15:18, Matthew 7:17-20, I John 5:17]. Pharisees Blaspheme: Do you think that the Pharisees blasphemed the Holy Spirit?