The Role of the Holy Spirit in Jesus: What was the role of the Holy Spirit have in Jesus' life? [Matthew 3:16, Philippians 2:7, Matthew 12:28]. The Holy Spirit Enables Us: Is the reason the Holy Spirit comes upon us, is it to enable us to live the Christian life in obedience? [Galatians 5:16, Galatians 5:22-23, Romans 8:2-4].